@bendurso Advantage+ is best if you have extremely broud targeting and let the campaign run for some days/weeks including flex ad sets that have a variety of creatives images/copy from my experience.
For me anything else than advantage+ on ad set level has not worked yet. usually the first sales come from 2x product price spend and it gets more once the campagn has enough data.
I am a beginner when it comes to adsm i have spend around 5-10k yet and advantage + has been the best performing so far in combination with dynamic creatives.
You can suggest amazing target groups to facebook, examples are izotope, thomann, fl studio, native instruments, ableton etc...